Track 1 - Optimisation
of existing vaccine candidates towards
Phase I trials
WP1 (Peter Andersen),
WP5 (Ann Rawkins) Selected number
of promising candidate vaccines
Optimisation of delivery and composition
Evaluation of safety, immunogenicity,
and protective efficacy in relevant
Second generation vaccine candidates
for downstream development in Phase
WP4 (Tom Ottenhoff)
Identify and develop human correlates
Identify and develop markers of TB
disease and TB immunopathology
Impact on the time and resources for
evaluation of vaccine candidates in
future clinical trials and early identification
of the most effective vaccines
WP6 (Paul-Henry Lambert)
Regulatory aspects of vaccine development
(ao. pre-clinical files)
Phase I clinical trials, in TB endemic
and non-endemic areas Selection of
candidates for further trials (involvement
Track 2 - New
WP2 (Carlos Martin)
Optimisation of (three) selected live
vaccine candidates that showed a distinct,
improved efficacy as compared to BCG
and show promise as vaccines in infants
Identification and effects immunomodulatory
Selection of candidates/ligands for
downstream development to Phase I
WP3 (Stefan Kaufmann)
Innovative back-up research to identify
and develop novel vaccines/antigen
components with a primary focus on
subunit vaccines based on dormancy
OFFER / PROJECT MANAGER IN VACCINE DEVELOPMENT
The goal is to develop
a live vaccine against tuberculosis within
the University of Zaragoza, Microbiology
Department, Faculty of Medicine. We are
looking for a Project Manager with the following
Product development plan
- Translate the project strategies and objectives
into a planning of activities.
- Contribute to the preparation of the Product
Development Plan with strategies, objectives,
schedules and major steps of development.
- Use the product development plan to prepare
technical and operational work plan with
well-timed activities and resources need.
Create planning / Gantt charts for the project.
- Analyze risks and opportunities, anticipate
pitfalls, list deliverables, and assist
in establishing the criteria for making
Implement and monitor workplan
- Assist Project Director in structuring
and setting up the Project Team and its
sub teams as well as in organizing operations.
- Organize regular technical meetings and
reviews done by the project and technical
teams. Prepare agendas and take the write
minutes of the meetings. Include a list
of actions and assignments. Distribute minutes
- From the work plan as a reference, monitor
progress of activities, quality of deliverables,
timing, and cost.
- Within the Project Team, report progress,
status according to plan and forecast. Highlight
changes or delay, and flag risks and pitfalls.
Develop corrective actions and plans to
- Update Gantt as needed.
- Interact with PM, partners, consultants
and contractors as needed.
- Assist the Project Director in reviews
- Participate in quarterly and annual project
- Coordinate and contribute to the writing
of proposals, reports, project descriptions,
and scopes of work, as requested.
- PhD in life sciences or commensurate experience.
- Scientific background in the science related
- At least 5 years of experience in project
management of vaccine development, preferably
from the bio-pharmaceutical industry.
- Experience in managing multiple projects
in an integrated way.
- Superior organizational skills.
- Strategic and analytical thinking.
- Ability to work in a multinational and
multi-cultural environment with project
teams, in a matrix organization.
- Excellent verbal and written communication
- Being skilled in Microsoft Project is
highly desirable. Use of web-based information
sharing is a plus.
- Commitment to PATH’s mission and
- Experience with international projects
- Knowledge of GLP, GCP and/or quality assurance
and regulatory affairs associated with vaccine
development is desirable.
A year-contract starting on April 2008,
renewable for a second one. Submit a statement
of scientific interests and accomplishments,
the names and addresses of at least three
references and a curriculum vitae to Dr.
Carlos Martin Department of Microbiology,
Faculty of Medicine, University of Zaragoza,
Calle Domingo Miral, Zaragoza 50009, Spain.
Electronic applications encouraged; send
Applications will be reviewed beginning
March 1, 2008.